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Cells from females also appear to be equipped with more efficient epigenetic machinery than the male counterpart.

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These findings indicate that sex effects must be considered in studies of the pharmacological control of defensive behaviors, and suggest that responsivity to sex effects may be an additional criterion for the suitability of animal models of anxiety.

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Differences have been detected in a number of either transmissible or non-transmissible diseases.

In particular, epidemiology clearly suggests that, apart from reproductive organs, several forms of cancers of great relevance, e.g., melanoma or leukemias, clearly display a gender disparity in terms of incidence, prevalence, or response to therapy [3].

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